Publications

2023

[123] Degradable Latexes by Nitroxide-Mediated Aqueous Seeded Emulsion Copolymerization Using a Thionolactone. Lages, M.; Gil, N.; Galanopoulo, P.; Mougin, J.; Lefay, C.; Guillaneuf, Y.; Lansalot, M.; D'Agosto, F.; Nicolas, J.* Macromolecules 2023, accepted.

[122] RAFT-Mediated Emulsion Polymerization-Induced Self-Assembly for the Synthesis of Core-Degradable Waterborne Particles. Galanopoulo, P.; Gil, N.; Gigmes, D.; Lefay, C.; Guillaneuf, Y.; Lages, M.; Nicolas, J.; D'Agosto, F.;* Lansalot, M.* Angew. Chem., Int. Ed. 2023, in press. DOI: 10.1002/anie.202302093

[121] Degradable Polyisoprene by Radical Ring-Opening Polymerization and Application to Polymer Prodrug Nanoparticles. Lages, M.; Pesenti, T.; Zhu, C.; Le, D.; Mougin, J.; Guillaneuf, Y.; Nicolas, J.* Chem. Sci. 2023, in press. DOI: 10.1039/d2sc05316k

[120] Degradable Vinyl Polymer Particles by Radical Aqueous Emulsion Copolymerization of Methyl Methacrylate and 5,6-Benzo-2-Methylene-1,3-Dioxepane. Galanopoulo, P.; Sinniger, L.; Gil, N.; Gigmes, D.; Lefay, C.; Guillaneuf, Y.; Lages, M.; Nicolas, J.; D'Agosto, F.;* Lansalot, M.* Polym Chem. 2023, in press. DOI: 10.1039/d3py00040k

[119] Increasing the Hydrophilicity of Cyclic Ketene Acetals Improves the Hydrolytic Degradation of Vinyl Copolymers and the Interaction of Glycopolymer Nanoparticles with Lectins. Pesenti, T.; Gillon, E.; Ishii, S.; Messaoudi, S.; Guillaneuf, Y.; Imberty, A.; Nicolas, J.* Biomacromolecules 2023, 24, 991. DOI: 10.1021/acs.biomac.2c01419

[118] In Situ Encapsulation of Biologically Active Ingredients into Polymer Particles by Polymerization in Dispersed Media. Lages, M.; Nicolas, J.* Prog. Polym. Sci. 2023, 137, 101637. DOI: 10.1016/j.progpolymsci.2022.101637 | Front cover

2022

[117] Degradable Vinyl Copolymer Nanoparticles/Latexes by Aqueous Nitroxide-Mediated Polymerization-Induced Self-Assembly. Lages, M.; Gil, N.; Galanopoulo, P.; Mougin, J.; Lefay, C.; Guillaneuf, Y.; Lansalot, M.; D'Agosto, F.; Nicolas, J.* Macromolecules 2022, 55, 9790. DOI: 10.1021/acs.macromol.2c01734

[116] A Polymer Prodrug Strategy to Switch from Intravenous to Subcutaneous Cancer Therapy for Irritant/Vesicant Drugs. Bordat, A.; Boissenot, T.; Ibrahim, N.; Ferrere, M.; Levêque, M.; Potiron, L.; Denis, S.; Garcia-Argote, S.; Carvalho, O.; Abadie, J.; Cailleau, C.; Pieters, G.; Tsapis, N.;* Nicolas, J.* J. Am. Chem. Soc. 2022, 144, 18844. DOI: 10.1021/jacs.2c04944 | Front cover

*Highlights*

• "Chemotherapy: towards a simplified subcutaneous administration", CNRS international press release (04-10-2022)
• "Une chimiothérapie simplifiée var voie sous-cutanée", Le Journal des Sciences, France Culture (04-10-2022)
• "Cancer: simplifier l’injection de la chimiothérapie", Le Figaro (05-10-2022)
• "Chimiothérapie : vers une administration simplifiée par voie sous-cutanée ?", Le Monde (05-10-2022)
• "Ça pourrait être un gros progrès : des scientifiques révolutionnent la chimiothérapie", Europe 1 (05-10-2022)
• "Cancer : une étude française apporte l'espoir d'une simplification des chimiothérapies", France Info (04-10-2022)
• "Science : et si les chimiothérapies s'injectaient avec une simple seringue ?", Les Echos (04-10-2022)
• "Cancer : La chimiothérapie pourrait être simplifiée, un espoir pour les malades", 20 Minutes (05-10-2022)
• "Une nouvelle piste de recherche pour faciliter l’administration des chimiothérapies", The Conversation (14-11-2022)
• "Chimiothérapies : un moyen pour passer de l’intra-veineux au sous-cutané", Science et Avenir (04-10-2022)
• "Chimiothérapie : vers la voie sous-cutanée", Le Progrès (15-10-2022)
• "Cancer : vers une chimiothérapie par voie sous-cutanée ?", Doctissimo (05-10-2022)
• "Chimiothérapie : bientôt une administration simplifiée sous la peau ?", Santé Magazine (05-10-2022)



Read more

[115] Degradable Glycopolyester-Like Nanoparticles by Radical Ring-Opening Polymerization. Pesenti, T.; Domingo-Lopez, D.; Gillon, E.; Ibrahim, N.; Messaoudi, S.;* Imberty, A.; Nicolas, J.* Biomacromolecules 2022, 23, 4015. DOI: 10.1021/acs.biomac.2c00851

[114] Degradable Polyampholytes from Radical Ring-Opening Copolymerization Enhance Cellular Cryopreservation. Pesenti, T.; Zhu, C.; Gonzalez-Martinez, N.; Tomás, R. M. F.; Gibson, M. I.;* Nicolas, J.* ACS Macro Letters 2022, 11, 889. DOI: 10.1021/acsmacrolett.2c00298

[113] (Bio)degradable and Biocompatible Nano-Objects from Polymerization-Induced and Crystallization-Driven Self-Assembly. Zhu, C.; Nicolas, J.* Biomacromolecules 2022, 23, 3043. DOI: 10.1021/acs.biomac.2c00230 | Front cover

[112] Vinyl Copolymers with Faster Hydrolytic Degradation than Aliphatic Polyesters and Tunable Upper Critical Solution Temperatures. Bossion, A.; Zhu, C.; Guerassimoff, L.; Mougin, J.; Nicolas, J.* Nature Commun. 2022, 13, 2873. DOI: 10.1038/s41467-022-30220-y

*Highlights*

• "Toward new degradable polymers", CNRS international press release (24-05-2022)
• "Un nouveau polymère dégradable", La Méthode Scientifique, France Culture (24-05-2022)
• "De nouveaux plastiques qui se dégradent rapidement dans l'eau", CQFD, Radio Télévision Suisse (25-05-2022)
• "De nouveaux polymères thermosensibles qui se dégradent très vite", Les Echos (03-06-2022)



Read more

[111] A Simple Route to Aqueous Suspensions of Degradable Copolymer Nanoparticles Based on Radical Ring-Opening Polymerization-Induced Self-Assembly (rROPISA). Zhu, C.; Denis, S.; Nicolas, J.* Chem. Mater. 2022, 34, 1875. DOI: 10.1021/acs.chemmater.1c04151

[110] One-Step Synthesis of Degradable Vinylic Polymer-Based Latexes via Aqueous Radical Emulsion Polymerization. Galanopoulo, P.; Gil, N.; Gigmes, D.; Lefay, C.; Guillaneuf, Y.; Lages, M.; Nicolas, J.; Lansalot, M.;* D'Agosto, F.* Angew. Chem., Int. Ed. 2022, 61, e202117498. DOI: 10.1002/anie.202117498

2021

[109] Supramolecular Organization of Polymer Prodrug Nanoparticles Revealed by Coarse-Grained Simulations. Gao, P.; Nicolas, J.;* Ha-Duong, T.* J. Am. Chem. Soc. 2021, 143, 42. DOI: 10.1021/jacs.1c05332

[108] Simulations of the Upper Critical Solution Temperature Behavior of Poly(Ornithine-co-Citrulline)s Using Martini-Based Coarse-Grained Force Fields. Molza, A.-E.; Gao, P.; Jakpou, J.; Nicolas, J.; Tsapis, N.; Ha-Duong, T.* J. Chem. Theory Comput. 2021, 17, 4499. DOI: 10.1021/acs.jctc.1c00140

[107] Towards Nanoparticles with Site-Specific Degradability by Ring-Opening Copolymerization Induced Self-Assembly in Organic Medium. Zhu, C.; Nicolas, J.* Polym. Chem. 2021, 12, 594. DOI: 10.1039/d0py01425g

2020

[106] 100th Anniversary of Macromolecular Science Viewpoint: Degradable Polymers from Radical Ring-Opening Polymerization (rROP): Latest Advances, New Directions and Ongoing Challenges. Pesenti, T.; Nicolas, J.* ACS Macro Letters 2020, 9, 1812. DOI: 10.1021/acsmacrolett.0c00676

[105] DFT Calculation-Assisted Prediction of the Copolymerization Between Cyclic Ketene Acetals with Traditional Vinyl Monomers. Tardy, A.; Gil, N.; Plummer, C.; Zhu, C.; Harrisson, S.; Siri, D.; Nicolas, J.; Gigmes, D.; Guillaneuf, Y.;* Lefay, C.* Polym. Chem. 2020, 11, 7159. DOI: 10.1039/d0py01179g

[104] Synthesis of Poly(Asparagine-co-Phenylalanine) Copolymers, Analogy with Thermosensitive Poly(Acrylamide-co-Styrene) Copolymers and Formation of PEGylated Nanoparticles. Bossion, A.; Nicolas, J.* Eur. Polym. J. 2020, 140, 110033. DOI: 10.1016/j.eurpolymj.2020.110033

[103] 3D Extracellular Matrix Mimics: Fundamental Concepts and Role of Materials Chemistry to Influence the Stem Cell Fate. Nicolas, J.; Magli, S.; Rabbachin, L.; Sampaolesi, S.; Nicotra, F.; Russo, L.* Biomacromolecules 2020, 21, 1968. DOI: 10.1021/acs.biomac.0c00045

2019

[102] The Crucial Role of Macromolecular Engineering, Drug Encapsulation and Dilution on the Thermoresponsiveness of UCST Diblock Copolymer Nanoparticles Used for Hyperthermia. Bordat., A.; Soliman, N.; Ben Chraït, I.; Manerlax, K.; Yagoubi, N.; Boissenot, T.; Nicolas, J.;* Tsapis, N.* Eur. J. Pharm. Biopharm. 2019, 142, 281. DOI: 10.1016/j.ejpb.2019.07.001

 

[101] Light Sheet Fluorescent Microscopy Versus Confocal Microscopy: In Quest of a Suitable Tool to Assess Drug and Nanomedicine Penetration into Multicellular Tumor Spheroids. Lazzari, G.; Vinciguerra, D.; Balasso, A.; Nicolas, V.; Goudin, N.; Garfa-Traore, M.; Féher, A.; Dinnyés, A.; Nicolas, J.; Couvreur, P.; Mura, S.* Eur. J. Pharm. Biopharm. 2019, 142, 195. DOI: 10.1016/j.ejpb.2019.06.019

 

[100] Protein-Functionalized Nanoparticles Derived from End-Functional Polymers and Polymer Prodrugs for Crossing the Blood-Brain Barrier. Cox, A.; Vinciguerra, D.; Re, F.;* Dal Magro, R.; Mura, S.; Masserini, M.; Couvreur, P.; Nicolas, J.* Eur. J. Pharm. Biopharm. 2019, 142, 70. DOI: 10.1016/j.ejpb.2019.06.004

 

[99] Drug-Initiated Synthesis of Heterotelechelic Polymer Prodrug Nanoparticles for Imaging and Cancer Cell Targeting. Vinciguerra, D.; Degrassi, A.; Mancini, L.; Mura, S.; Mougin, J.; Couvreur, P.; Nicolas, J.* Biomacromolecules 2019, 20, 2464. DOI: 10.1021/acs.biomac.9b00148

 

[98] Radical Ring-Opening Copolymerization-Induced Self-Assembly (rROPISA). Guégain, E.; Zhu, C.; Giovanardi, E.; Nicolas, J.* Macromolecules 2019, 52, 3612. DOI: 10.1021/acs.macromol.9b00161

 

[97] Structure-pDNA Complexation and Structure-Cytotoxicity Relationships of PEGylated, Cationic Aminoethyl-Based Polyacrylates with Tunable Topologies. Le Bohec, M.; Bonchouo Kenzo, K.; Piogé, S.; Mura, S.; Nicolas, J.; Casse, N.; Forcher, G.; Fontaine, L.; Pascual, S. Polym. Chem. 2019, 10, 1968. DOI: 10.1039/c8py01776j

 

[96] From Poly(Alkyl Cyanoacrylate) to Squalene as Core Material to Design Nanomedicines. Mura, S.; Fattal, E.;* Nicolas, J. J. Drug Target. 2019, 27, 470. DOI: 10.1080/1061186X.2019.1579822

 

[95] Cathepsin-Sensitive Nanoscale Drug Delivery Systems for Cancer Therapy and other Diseases. Dheer, D.; Nicolas, J.;* Shankar, R.* Adv. Drug Deliv. Rev. 2019, 151-152, 130. DOI: 10.1016/j.addr.2019.01.010

 

[94] Heterotelechelic Polymer Prodrug Nanoparticles: Adaptability to Different Drug Combinations and Influence of the Dual Functionalization on the Cytotoxicity. Vinciguerra, D.; Jacobs, M.; Denis, S.; Mougin, J.; Guillaneuf, Y.; Lazzari, G.; Zhu, C.; Mura, S.; Couvreur, P., Nicolas, J.* J. Control. Release 2019, 295, 223. DOI: 10.1016/j.jconrel.2018.12.047

 

[93] Degradable Copolymer Nanoparticles from Radical Ring-Opening Copolymerization Between Cyclic Ketene Acetals and Vinyl Ethers. Tran, J.; Pesenti, T.; Cressonnier, J.; Lefay.; C.; Guillaneuf, Y.; Nicolas, J.* Biomacromolecules 2019, 20, 305. DOI: 10.1021/acs.biomac.8b01500 | Front cover

 

[92] Thermoresponsive Polymer Nanocarriers for Biomedical Applications. Bordat, A.; Boissenot, T.; Nicolas, J.; Tsapis, N.* Adv. Drug Deliv. Rev. 2019, 138, 167. DOI: 10.1016/j.addr.2018.10.005

2018

[91] Degradable Polymer Prodrugs with Adjustable Activity from Drug-Initiated Radical Ring-Opening Copolymerization. Guégain, E.; Tran, J.; Deguettes, Q.; Nicolas, J.* Chem. Sci. 2018, 9, 8291. DOI: 10.1039/c8sc02256a

 

[90] A Facile Route to Heterotelechelic Polymer Prodrug Nanoparticles for Imaging, Drug Delivery and Combination Therapy. Vinciguerra, D.; Denis, S.; Mougin, J.; Jacobs, M.; Guillaneuf, Y.; Mura, S.; Couvreur, P.; Nicolas, J.* J. Control. Release 2018, 286, 485. DOI: 10.1016/j.jconrel.2018.08.013

 

[89] Tunable Degradation of Copolymers Prepared by Nitroxide-Mediated Radical Ring-Opening Polymerization and Point-by-Point Comparison with Traditional Polyesters. Guégain, E.; Michel, J.-P.; Boissenot, T.; Nicolas, J.* Macromolecules 2018, 51, 724. DOI: 10.1021/acs.macromol.7b02655

 

[88] Incomplete Copolymer Degradation of In Situ Chemotherapy. Bourdillon, P.;* Boissenot, T.; Goldwirt, L.; Nicolas, J.; Apra, C.; Carpentier, A. J. Mater. Sci.: Mater. Med. 2018, 29, 25. DOI: 10.1007/s10856-018-6032-x

 

[87] Self-Stabilized, Hydrophobic or PEGylated Paclitaxel Polymer Prodrug Nanoparticles for Cancer Therapy. Bao, Y.; Guégain, E.; Mougin, J.; Nicolas, J.* Polym. Chem. 2018, 9, 687. DOI: 10.1039/c7py01918a | Front cover | Paper of the month

 

[86] Antibody-Functionalized Polymer Nanoparticle Leading to Memory Recovery in Alzheimer’s Disease-like Transgenic Mouse Model. Carradori, D.; Balducci, C.; Re, F.;* Brambilla, D.; Le Droumaguet, B.; Flores, O.; Gaudin¸ A.; Mura, S.; Forloni, G.; Ordoñez-Gutierrez, L.; Wandosell, F.; Masserini, M.; Couvreur, P.; Nicolas, J.;* Andrieux, K. Nanomedicine NBM 2018, 14, 609. DOI: 10.1016/j.nano.2017.12.006

 

[85] Telechelic Polymers from Reversible-Deactivation Radical Polymerization for Biomedical Applications. Vinciguerra, D.; Tran, J.; Nicolas, J.;* Chem. Commun. 2018, 54, 228. DOI: 10.1039/c7cc08544c

2017

[84] Radical Copolymerization of Vinyl Ethers and Cyclic Ketene Acetals as a Versatile Platform to Design Functional Polyesters. Tardy, A.; Honoré, J.-C.; Tran, J.; Siri, D.; Delplace, V.; Bataille, I.; Letourneur, D.; Perrier, J.; Nicoletti, S.; Maresca, M.; Lefay, C.; Gigmes, D.; Nicolas, J.;* Guillaneuf, Y.* Angew. Chem., Int. Ed. 2017, 56, 16515. DOI: 10.1002/anie.201707043

 

[83] Radical Ring-Opening Copolymerization of Cyclic Ketene Acetals and Maleimides Affords Homogeneous Incorporation of Degradable Units. Hill, M. R.; Guégain, E.; Tran, J.; Figg, C. A.; Turner, A. C.; Nicolas, J.*, Sumerlin, B. S.* ACS Macro Lett. 2017, 6, 1071. DOI: 10.1021/acsmacrolett.7b00572

 

[82] Structure-Cytotoxicity Relationship of Drug-Initiated Polymer Prodrug Nanoparticles. Bao.; Y.; Nicolas, J.* Polym. Chem. 2017, 8, 5174. DOI: 10.1039/c7py00536a

 

[81] Fluorescent Polymer Prodrug Nanoparticles with Aggregation-Induced Emission (AIE) Properties from Nitroxide-Mediated Polymerization. Bao.; Y.; Guégain, E.; Nicolas, V.; Nicolas, J.* Chem. Commun. 2017, 53, 4489. DOI: 10.1039/c6cc09052d

 

[80] A Comprehensive Kinetic Study of the Conventional Free-Radical Polymerization of Seven-Membered Cyclic Ketene Acetals. Tardy, A.; Honoré, J.-C.; Siri, D.; Nicolas, J.; Gigmes, D.; Lefay, C.; Guillaneuf, Y.* Polym. Chem. 2017, 8, 5139. DOI: 10.1039/c7py00337d

 

[79] Polymer Nanoparticles for the Delivery of Anticancer Drugs. Nicolas, J.;* Couvreur. P. Med./Sci. 2017, 33, 11. DOI: 10.1051/medsci/20173301003

 

[78] Radical Ring-Opening Polymerization: Scope, Limitations and Application to (Bio)Degradable Materials. Tardy, A.; Nicolas, J.; Gigmes, D.; Lefay, C.;* Guillaneuf, Y.* Chem. Rev. 2017, 117, 1319. DOI: 10.1021/acs.chemrev.6b00319

2016

[77] Pulmonary Surfactant Protein A: A Mediated Enrichment of Surface-Decorated Polymeric Nanoparticles in Alveolar Macrophages. Ruge, C. A.; Hillaireau, H.; Grabowski, N.; Beck-Broichsitter, M.; Cañadas, O.; Tsapis, N.; Casals, C.; Nicolas, J.; Fattal, E.* Mol. Pharm. 2016, 13, 4168. DOI: 10.1021/acs.molpharmaceut.6b00773

[76] Simple Synthesis of Cladribine-Based Anticancer Polymer Prodrug Nanoparticles with Tuneable Drug Delivery Properties. Bao, Y.; Boissenot, T.; Guégain, E.; Desmaële, D.; Mura, S.; Couvreur, P.; Nicolas, J.* Chem. Mater. 2016, 28, 6266. DOI: 10.1021/acs.chemmater.6b02502

[75] Efficient Synthesis of 2-Methylene-4-Phenyl-1,3-Dioxolane, a Cyclic Ketene Acetal for Controlling the NMP of Methyl Methacrylate and Conferring Tunable Degradability. Tran, J.; Guégain, E.; Ibrahim, N.; Harrisson, S.; Nicolas, J.* Polym. Chem. 2016, 7, 4427. DOI: 10.1039/c6py00778c

[74] Drug-Initiated Synthesis of Polymer Prodrugs: Combining Simplicity and Efficacy in Drug Delivery. Nicolas, J.* Chem. Mater. 2016, 28, 1591. DOI: 10.1021/acs.chemmater.5b04281 (invited Perspective article) | Front cover

[73] Nitroxide-Mediated Polymerization of Vinyl Chloride at Low Temperature: Kinetic and Computational Studies. Abreu, C. M. R.; Mendonça, P. V.; Serra, A. C.; Noble, B. B.; Guliashvili, T.;* Nicolas, J.;* Coote, M. L.;* Coelho, J. F. J.* Macromolecules 2016, 49, 490. DOI: 10.1021/acs.macromol.5b02017

[72] Cyclopentyl Methyl Ether as a Green Solvent for Reversible-Addition Fragmentation Chain Transfer and Nitroxide-Mediated Polymerizations. Abreu, C. M. R.; Maximiano, P.; Guliashvili, T.; Nicolas, J.;* Serra, A. C.; Coelho, J. F. J.* RSC Advances 2016, 6, 7495. DOI: 10.1039/c5ra21975b

2015

[71] Degradable Vinyl Polymers for Biomedical Applications. Delplace, V.; Nicolas, J.* Nature Chem. 2015, 7, 771. DOI: 10.1038/nchem.2343 | Front cover

[70] A Ring to Rule Them All: A Cyclic Ketene Acetal Comonomer Controls the Nitroxide-Mediated Polymerization of Methacrylates and Confers Tunable Degradability. Delplace, V.; Guégain, E.; Harrisson, S.; Gigmes, D.; Guillaneuf, Y.; Nicolas, J.* Chem. Commun. 2015, 51, 12847. DOI: 10.1039/c5cc04610f

[69] Solvent Selection Causes Remarkable Shifts of the “Ouzo Region” for Poly(Lactide-co-Glycolide) Nanoparticles Prepared by Nanoprecipitation. Beck-Broichsitter, M.; Nicolas, J.; Couvreur, P.* Nanoscale 2015, 7, 9215. DOI: 10.1039/c5nr01695a

[68] Design Attributes of Long-Circulating Polymeric Drug Delivery Vehicles. Beck-Broichsitter, M.; Nicolas, J.; Couvreur, P.* Eur. J. Pharm. Biopharm. 2015, 97, Part B, 304. DOI: 10.1016/j.ejpb.2015.03.033

[67] One-Step Synthesis of Azlactone-Functionalized SG1-Based Alkoxyamine for Nitroxide-Mediated Polymerization and Bioconjugation. Delplace, S.; Harrisson, S.; Ho, H. T.; Tardy, A.; Guillaneuf, Y.; Pascual, S.; Fontaine, L.; Nicolas, J.* Macromolecules 2015, 48, 2087. DOI: 10.1021/acs.macromol.5b00178

[66] On the Structure-Control Relationship of Amide-Functionalized SG1-Based Alkoxyamines for Nitroxide-Mediated Polymerization and Conjugation. Guégain, E.; Delplace, V.; Trimaille, T.; Gigmes, D.; Siri, D.; Marque, S.; Guillaneuf, Y.; Nicolas, J.* Polym. Chem. 2015, 6, 5693. DOI: 10.1039/c5py00283d | Feature article in Polym. Chem. Emerging Investigator issue 2015

 

[65] Nitroxide-Mediated Polymerization of Methacrylic Esters: Insights and Solutions to a Long Standing Problem. Guégain, E.; Guillaneuf, Y.; Nicolas, J.* Macromol. Rapid Commun. 2015, 36, 1227. DOI: 10.1002/marc.201500042 | Front cover

 

[64] Lipid Prodrug Nanocarriers in Cancer Therapy. Mura, S.;* Bui, D. T., Couvreur, P.; Nicolas, J.* J. Control. Release 2015, 28, 25. DOI: 10.1016/j.jconrel.2015.01.021

 

2014

[63] In the (Very) Long Run We Are All Dead: Activation and Termination in SET-LRP/SARA-ATRP. Harrisson, S.;* Nicolas, J. ACS Macro Lett. 2014, 3, 643. DOI: 10.1021/mz500305j

[62] Significant Tumor Growth Inhibition from Naturally Occurring Lipid-Containing Polymer Prodrug Nanoparticles Obtained by the Drug-Initiated Method. Maksimenko, A.; Bui, D. T.; Desmaële, D.; Couvreur P.; Nicolas, J.* Chem. Mater. 2014, 26, 3606. DOI: 10.1021/cm501500k

[61] Precise Engineering of Multifunctional PEGylated Polyester Nanoparticles for Cancer Cell Targeting and Imaging. Mackiewicz, N.; Nicolas, J.;* Handké, N.; Noiray, M.; Mougin, J.; Daveu, C.; Reddy, L. H.; Bazile, D.; Couvreur, P. Chem. Mater. 2014, 26, 1834. DOI: 10.1021/cm403822w

[60] RGD Decoration of PEGylated Polyester Nanocapsules of Perfluorooctyl Bromide for Tumor Imaging: Influence of Pre- or Post-Functionalization on Capsule Morphology. Diou, O.; Fattal, E.; Delplace, V.; Mackiewicz, N.; Nicolas, J.; Mériaux, S.; Valette, J.; Robic, C.; Tsapis, N.* Eur. J. Pharm. Biopharm. 2014, 87, 170. DOI: 10.1016/j.ejpb.2013.12.003

[59] Nitroxide-Mediated Radical Ring-Opening Copolymerization: Chain-End Investigation and Block Copolymer Synthesis. Delplace, V.; Harrisson, S.; Tardy, A.; Gigmes, D.; Guillaneuf, Y.; Nicolas, J.* Macromol. Rapid Commun. 2014, 35, 484. DOI: 10.1002/marc.201300809

[58] Recent Trends in the Design of Anticancer Polymer Prodrug Nanocarriers. Delplace, V.; Couvreur, P.; Nicolas, J.* Polym. Chem. 2014, 5, 1529. DOI: 10.1039/c3py01384g

[57] Multifunctional Squalene-Based Prodrug Nanoparticles for Targeted Cancer Therapy. Bui, D. T.; Nicolas, J.;* Maksimenko, A.; Desmaële, D.; Couvreur, P. Chem. Commun. 2014, 50, 5336. DOI: 10.1039/c3cc47427e | Feature article in Chem. Commun. Emerging Investigator issue 2014

2013

[56] Degradable PEG-Based and Comblike Copolymers by Nitroxide-Mediated Radical Ring-Opening Polymerization. Delplace, V.; Tardy, A.; Harrisson, S.; Mura, S.; Gigmes, D.; Guillaneuf, Y.; Nicolas, J.* Biomacromolecules 2013, 14, 3769. DOI: 10.1021/bm401157g

[55] Stimuli-Responsive Nanocarriers for Drug Delivery. Mura, S.; Nicolas, J.; Couvreur, P.* Nature Mater. 2013, 12, 991. DOI: 10.1038/nmat3776

[54] Polymer Prodrug Nanoparticles Based on Naturally Occurring Isoprenoid for Anticancer Therapy. Bui, D. T.; Maksimenko, A.; Desmaële, D.; Harrisson, S.; Vauthier, C.; Couvreur, P.; Nicolas, J.* Biomacromolecules 2013, 14, 2837. DOI: 10.1021/bm400657g

[53] Scope and Limitations of the Nitroxide-Mediated Radical Ring Opening Polymerization of Cyclic Ketene Acetals. Tardy, A.; Delplace, V.; Siri, D.; Lefay, C.; Harrisson, S.; de Fatima Albergaria Pereira, B.; Charles, L.; Gigmes, D.;* Nicolas, J.; Guillaneuf, Y.* Polym. Chem. 2013, 4, 4776. DOI: 10.1039/c3py00719g | Paper of the week

[52] Solution Phase and Nanoparticular Biosynthetically Inspired Interconnections in the Canthin-6-one ß-Carboline Series and Study of Phenotypic Properties on C. elegans. Cebrián-Torrejón, G.; Mackiewicz, N.; Vázquez-Manrique, R.; Fournet, A.; Figadère, B.; Nicolas, J.; Poupon, E.* Eur. J. Org. Chem. 2013, 5821. DOI: 10.1002/ejoc.201300770 | Front cover

[51] Effect of Nanoparticles Binding Beta-Amyloid Peptide on Nitric Oxide Production by Cultured Endothelial Cells and Macrophages. Orlando, F.; Re, F.; Sesana, S.; Rivolta, I.; Panariti, A.; Brambilla, D.; Nicolas, J.; Couvreur, P.; Andrieux, K.; Masserini, M.; Cazzaniga, E. Int. J. Nanomed. 2013, 8, 1335. DOI: 10.2147/ijn.s40297

[50] Nanoparticles with In Vivo Anticancer Activity from Polymer Prodrug Amphiphiles Prepared by Living Radical Polymerization. Harrisson, S.; Nicolas, J.;* Maksimenko, A.; Bui, D. T.; Mougin, J.; Couvreur, P. Angew. Chem., Int. Ed. 2013, 52, 1678. DOI: 10.1002/anie.201207297

[49] Facile Synthesis of Multicompartment Micelles Based on Biocompatible Poly(3-hydroxyalkanoate). Babinot, J.; Le Droumaguet, B.; Renard, E.; Guigner, J.-M.; Mura, S.; Nicolas, J.; Couvreur, P.; Langlois, V.* Macromol. Rapid Commun. 2013, 34, 362. DOI: 10.1002/marc.201200692

[48] Design, Functionalization Strategies and Biomedical Applications of Targeted Biodegradable/Biocompatible Polymer-Based Nanoparticles for Drug Delivery. Nicolas, J.;* Mura, S.; Brambilla, D.; Mackiewicz, N.; Couvreur, P. Chem. Soc. Rev. 2013, 42, 1147. DOI: 10.1039/c2cs35265f

[47] Nitroxide-Mediated Polymerization. Nicolas, J.;* Guillaneuf, Y.;* Lefay, C.; Bertin, D.; Gigmes, D.; Charleux, B. Prog. Polym. Sci. 2013, 38, 63. DOI: 10.1016/j.progpolymsci.2012.06.002

2012

[46] Comproportionation versus Disproportionation in the Initiation step of Cu(0)-Mediated Living Radical Polymerization. Harrisson, S.;* Couvreur, P.; Nicolas, J.* Macromolecules 2012, 45, 7388. DOI: 10.1021/ma301034t

[45] PEGylated Nanoparticles Bind to and Alter Amyloid-Beta Peptide Conformation: Towards Engineering of Functional Nanomedicines for Alzheimer’s Disease. Brambilla, D.; Verpillot, R.; Le Droumaguet, B.; Nicolas, J.; Taverna, M.; Kóna, J.; Lettiero, B.; Hashemi, S. H.; De Kimpe, L.; Canovi, M.; Gobbi, M.; Nicolas, V.; Scheper, W.; Moghimi, S. M.; Tvaroška, I.; Couvreur, P.; Andrieux, K.* ACS Nano 2012, 6, 5897. DOI: 10.1021/nn300489k

[44] Versatile and Efficient Targeting from a Single Nanoparticulate Platform: Application to Cancer and Alzheimer’s Disease. Le Droumaguet, B.; Nicolas, J.;* Brambilla, D.; Mura, S.; Maksimenko, A.; De Kimpe, L.; Salvati, E.; Zona, C.; Airoldi, C.; Canovi, M.; Gobbi, M.; Noiray, M.; La Ferla, B.; Nicotra, F.; Scheper, W.; Flores, O.; Masserini, M.; Andrieux, K.; Couvreur, P. ACS Nano 2012, 6, 5866. DOI: 10.1021/nn3004372

[43] Magnetic Nanoparticles: Design and Characterization, Toxicity and Biocompatibility, Pharmaceutical and Biomedical Applications. Harivardhan Reddy, L.; Arias, J. L.; Nicolas, J.; Couvreur, P.* Chem. Rev. 2012, 112, 5818. DOI: 10.1021/cr300068p

[42] Use of Solvent Effects to Improve Control over Nitroxide-Mediated Polymerization of Isoprene. Harrisson, S.; Couvreur, P.; Nicolas, J.* Macromol. Rapid Commun. 2012, 33, 805. DOI: 10.1002/marc.201100866 | Feature article in Macromol. Rapid Commun. Polymer Science: The Next Generation issue

[41] NIR-Labelling of PLGA Nanoparticles for In Vivo Imaging. Reul, R.; Tsapis, N.*; Hillaireau, H.; Sancey, L.; Mura, S.; Recher, M.; Nicolas, J.; Coll, J.-L.; Fattal, E. Polym. Chem. 2012, 3, 694. DOI: 10.1039/c2py00520d

2011

[40] SG1 Nitroxide-Mediated Polymerization of Isoprene: Alkoxyamine Structure/Control Relationship and a,w-Chain-End Functionalization. Harrisson, S.; Couvreur, P.; Nicolas, J.* Macromolecules 2011, 44, 9230. DOI: 10.1021/ma202078q

[39] Biodegradable Nanoparticles Meet the Bronchial Airway Barrier: How Surface Properties Affect Their Interaction with Mucus and Epithelial Cells. Mura, S.; Hillaireau, H.; Nicolas, J.; Kerdine-Römer, S.; Le Droumaguet, B.; Deloménie, C.; Nicolas, V.; Pallardy, M.; Tsapis, N.; Fattal, E.* Biomacromolecules 2011, 12, 4136 . DOI: 10.1021/bm201226x

[38] Influence of Surface Charge on the Potential Toxicity of PLGA Nanoparticles Towards Calu-3 Cells. Mura, S.; Hillaireau, H.; Nicolas, J.; Le Droumaguet, B.; Geutin, C.; Zanna, S.; Tsapis, N.; Fattal, E.* Int. J. Nanomed. 2011, 6, 2591. DOI: 10.2147/ijn.s24552

[37] Colloidal Properties of Biodegradable Nanoparticles Influence Interaction with Amyloid-ß Peptide. Brambilla, D.; Souguir, H., Nicolas, J.;* Mackiewicz, N.; Verpillot, R.; Le Droumaguet, B.; Taverna, M.; Couvreur, P.; Andrieux, K. J. Biotechnol. 2011, 156, 338. DOI: 10.1016/j.jbiotec.2011.07.020

[36] Quantum Dot-Loaded PEGylated Poly(alkyl cyanoacrylate) Nanoparticles for In Vitro and In Vivo Imaging. Nicolas, J.;* Brambilla, D.; Carion, O.; Pons, T.; Maksimovic, I.; Larquet, E.; Le Droumaguet, B.; Andrieux, K.; Dubertret, B.; Couvreur, P. Soft Matter 2011, 7, 6187. DOI: 10.1039/c1sm05529a

[35] Simple and Efficient Copper Metal-Mediated Synthesis of Alkoxyamines. Harrisson, S.; Couvreur, P.; Nicolas, J.* Polym. Chem. 2011, 2, 1853. DOI: 10.1039/c1py00131k

[34] Nanotechnologies and Alzheimer’s Disease: Diagnosis, Therapy and Safety Issues. Brambilla, D.; Le Droumaguet, B.; Nicolas, J.;* Hashemi, S. H.; Wu, L.-P.; Moghimi, S. M.; Couvreur, P.; Andrieux, K. Nanomedicine: NBM 2011, 7, 521. DOI: 10.1016/j.nano.2011.03.008

[33] First Peptide/Protein PEGylation with Functional Polymers Designed by Nitroxide-Mediated Polymerization. Chenal, M.; Boursier, C.; Guillaneuf, Y.; Taverna, M.; Couvreur, P.; Nicolas, J.* Polym. Chem. 2011, 2, 1523. DOI: 10.1039/c1py00028d

[32] Selegiline-Functionalized, PEGylated Poly(alkyl cyanoacrylate) Nanoparticles: Investigation of Interaction with Amyloid-ß Peptide and Surface Reorganization. Le Droumaguet, B.; Souguir, H.; Brambilla, D.; Verpillot, R.; Nicolas, J.;* Taverna, M.; Couvreur, P.; Andrieux, K.* Int. J. Pharm. 2011, 416, 453. DOI: 10.1016/j.ijpharm.2011.01.015

2010

[31] A New Method Based on Capillary Electrophoresis with Laser-Induced Fluorescence Detection (CE-LIF) to Monitor Interaction Between Nanoparticles and the Amyloid-ß Peptide. Brambilla, D.; Verpillot, R.; Taverna, M.*; De Kimpe, L.; Le Droumaguet, B.; Nicolas, J.; Canovi, M.; Gobbi, M.; Mantegazza, F.; Salmona, M.; Nicolas, V.; Scheper, W.; Couvreur, P.; Andrieux, K. Anal. Chem. 2010, 82, 10083. DOI: 10.1021/ac102045x

[30] Facile Synthesis of Innocuous Comb-Shaped Polymethacrylates with PEG Side Chains by Nitroxide-Mediated Radical Polymerization in Hydroalcoholic Solutions. Chenal, M.; Mura, S.; Marchal, C.; Gigmes, D.; Charleux, B.; Fattal, E.; Couvreur, P.; Nicolas, J.* Macromolecules 2010, 43, 9291. DOI: 10.1021/ma101880m

[29] PEGylation and Preliminary Biocompatibility Evaluation of Magnetite-Silica Nanocomposites Obtained by High Energy Ball Milling. Pilloni, M.; Nicolas, J.;* Marsaud, V.; Bouchemal, K.; Frongia, F.; Scano, A.; Ennas, G.; Dubernet, C. Int. J. Pharm. 2010, 401, 103. DOI: 10.1016/j.ijpharm.2010.09.010

[28] Design of Fluorescently Tagged Poly(alkyl cyanoacrylate) Nanoparticles for Human Brain Endothelial Cell Imaging. Brambilla, D.; Nicolas, J.;* Le Droumaguet, B.; Andrieux, K.*; Marsaud, V.; Couraud, P.-O.; Couvreur, P. Chem. Commun. 2010, 46, 2602. DOI: 10.1039/b924028d

[27] Recent Advances in the Design of Bioconjugates from Controlled/Living Radical Polymerization. Le Droumaguet, B.; Nicolas, J.* Polym. Chem. 2010, 1, 563. DOI: 10.1039/b9py00363k | Front cover | Author of the week

[26] A Minimal Amount of Acrylonitrile Turns the Nitroxide-Mediated Polymerization of Methyl Methacrylate Into an Almost Ideal Controlled/Living System. Nicolas, J.;* Brusseau, S.; Charleux, B.* J. Polym. Sci., Part A: Polym. Chem. 2010, 48, 34. DOI: 10.1002/pola.23749

2009

[25] Formulation of Didanosine Prodrugs into PEGylated Poly(alkyl cyanoacrylate) Nanoparticles and Uptake by Brain Endothelial Cells. Pierson, L.-A; Nicolas, J.; Lalanne, M.; Brambilla, D.; Marsaud, V.; Nicolas, V.; Ball, R.; Stanimirovic, D.; Couvreur, P.; Andrieux, K.* J. Nanoneurosci. 2009, 1, 174. DOI: 10.1166/jns.2009.1007

[24] Application of Thermal Analysis to the Study of Lipidic Prodrug Incorporation Into Nanocarriers. Bourgeois, J.; Pierson, L.-A.; Nicolas, J.; Lalanne, M.; Couvreur, P.; Andrieux, K.* J. Therm. Anal. Cal. 2009, 98, 65. DOI: 10.1007/s10973-009-0350-7

[23] Comprehensive Modeling Study of Nitroxide-Mediated Controlled/Living Radical Copolymerization of Methyl Methacrylate with a Small Amount of Styrene. Nicolas, J.;* Mueller, L.; Dire, C.; Matyjaszewski, K.; Charleux, B.* Macromolecules 2009, 44, 4470. DOI: 10.1021/ma900515v

[22] Synthesis of Poly(alkyl cyanoacrylate)-Based Colloidal Nanomedicines. Nicolas, J.;* Couvreur, P. Wiley Interdiscipl. Rev. Nanomed. Nanobiotechnol. 2009, 1, 111. DOI: 10.1002/wnan.15

2008

[21] Novel PEGylated Nanoassemblies Made of Self-Assembled Squalenoyl Nucleoside Analogues. Bekkara-Aounallah, F.; Gref, R.*; Othman, M.; Reddy, H.; Pili, B.; Allain, V.; Bourgaux, C.; Hillaireau, H.; Lepêtre-Mouelhi, S.; Desmaële, D.; Nicolas, J.; Chafi, N.; Couvreur, P. Adv. Funct. Mater. 2008, 18, 3715. DOI: 10.1002/adfm.200800705

[20] Synthesis of Highly Functionalized Poly(alkyl cyanoacrylate) Nanoparticles by Means of Click Chemistry. Nicolas, J.;* Bensaid, F.; Desmaële, D.; Grogna, M.; Detrembleur, D.; Andrieux, K.; Couvreur, P. Macromolecules 2008, 41, 8418. DOI: 10.1021/ma8013349

[19] Beta-Hydrogen Transfer from Poly(methyl methacrylate) Propagating Radicals to the Nitroxide SG1: Analysis of the Chain-end and Determination of the Rate Constant. Dire, C.; Belleney, J.; Nicolas, J.; Bertin, D.; Magnet, S.; Charleux, B.* J. Polym. Sci., Part A: Polym. Chem. 2008, 46, 6333. DOI: 10.1002/pola.22945

[18] Comblike Polymethacrylates with Poly(ethylene glycol) Side Chains via Nitroxide-Mediated Controlled Free-Radical Polymerization. Nicolas, J.;* Couvreur, P.; Charleux, B. Macromolecules 2008, 41, 3758. DOI: 10.1021/ma800609b

[17] Separation of Complex Branched Polymers by Size-Exclusion Chromatography Probed with Multiple Detection. Gaborieau, M.; Nicolas, J.; Save, M.; Charleux, B.; Vairon, J.-P.; Gilbert, R. G.; Castignolles, P.* J. Chromatogr. A 2008, 1190, 215. DOI: 10.1016/j.chroma.2008.03.031

2007

[16] Site-Directed Conjugation of "Clicked" Glycopolymers to Form Glycoprotein Mimics: Binding to Mammalian Lectin and Induction of Immunological Function. Geng, J.; Mantovani, G.*; Tao, L.; Nicolas, J.; Chen, G.; Wallis, R.; Mitchell, D. A.; Johnson, B. R. G.; Evans, S. D.; Haddleton, D. M.* J. Am. Chem. Soc. 2007, 129, 15156. DOI: 10.1021/ja072999x

[15] Nanostructured Latex Particles Synthesized by Nitroxide-Mediated Controlled/Living Free-Radical Polymerization in Emulsion. Nicolas, J.;* Ruzette, A.-V.; Farcet, C.; Gérard, P.; Magnet, S.; Charleux, B.* Polymer 2007, 48, 7029. DOI: 10.1016/j.polymer.2007.09.039

[14] Water-Soluble SG1-Based Alkoxyamines: a Breakthrough in Controlled/Living Free-Radical Polymerization in Aqueous Dispersed Media. Charleux, B.*; Nicolas, J. Polymer 2007, 48, 5813. DOI: 10.1016/j.polymer.2007.07.031 | Front cover

[13] Living Radical Polymerization as a Tool for the Synthesis of Polymer-Protein/Peptide Bioconjugates. Nicolas, J.;* Mantovani, G.; Haddleton, D. M.* Macromol. Rapid Commun. 2007, 28, 1083. DOI: 10.1002/marc.200700112

[12] Bioconjugation onto Biological Surfaces with Fluorescently Labeled Polymers. Nicolas, J.; Khoshdel, E.; Haddleton, D. M.* Chem. Commun. 2007, 1722. DOI: 10.1039/b617596a

2006

[11] Living Character of Polymer Chains Prepared via Nitroxide-Mediated Controlled Free-Radical Polymerization of Methyl Methacrylate in the Presence of a Small Amount of Styrene at Low Temperature. Nicolas, J.; Dire, C.; Mueller, L.; Belleney, J.; Charleux, B.*; Marque, S. R. A.; Bertin, D.; Magnet, S.; Couvreur, L. Macromolecules 2006, 39, 8274. DOI: 10.1021/ma061380x

[10] Fluorescently Tagged Polymer Bioconjugates from Protein Derived Macroinitiators. Nicolas, J.; San Miguel, V.; Mantovani, G.; Haddleton, D. M.* Chem. Commun. 2006, 4697. DOI: 10.1039/b609935a

[9] Multistep and Semi-Batch Nitroxide-Mediated Controlled Free-Radical Emulsion Polymerization: A Significant Step Toward Conceivable Industrial Processes. Nicolas, J.; Charleux, B.*; Magnet, S. J. Polym. Sci., Part A: Polym. Chem. 2006, 44, 4142. DOI: 10.1002/pola.21519

[8] Aqueous Suspension of Amphiphilic Diblock Copolymer Nanoparticles Prepared in Situ from a Water-Soluble Poly(sodium acrylate) Alkoxyamine Macroinitiator. Delaittre, G.; Nicolas, J.; Lefay, C.; Save,M.; Charleux, B.* Soft Matter 2006, 2, 223. DOI: 10.1039/b515267d

2005

[7] Nitroxide-Mediated Controlled Free-Radical Emulsion Polymerization Using a Difunctional Water-Soluble Alkoxyamine Initiator. Toward the Control of Particle Size, Particle Size Distribution and the Synthesis of Triblock Copolymers. Nicolas, J.; Charleux, B.*; Guerret, O.; Magnet, S. Macromolecules 2005, 38, 9963. DOI: 10.1021/ma0511999

[6] Miniemulsion Polymerization of Styrene using a pH-Responsive Cationic Diblock Copolymer and its Reactive Copolymer Counterpart as Stabilizers. Houillot, L.; Nicolas, J.; Save, M.*; Charleux, B.; Li, Y.; Armes, S. P. Langmuir 2005, 21, 6726. DOI: 10.1021/la050495b

[5] Theoretical Expression of the Average Activation-Deactivation Equilibrium Constant in Controlled/Living Free-Radical Copolymerization Operating via Reversible Termination. Application to a Strongly Improved Control in Nitroxide-Mediated Polymerization of Methyl Methacrylate. Charleux, B.*; Nicolas, J.; Guerret, O. Macromolecules 2005, 38, 5485. DOI: 10.1021/ma050087e

[4] Surfactant-Free Synthesis of Amphiphilic Diblock Copolymer Nanoparticles via Nitroxide-Mediated Controlled Free-Radical Polymerization. Delaittre, G.; Nicolas, J.; Lefay, C.; Save, M.; Charleux, B.* Chem. Commun. 2005, 614. DOI: 10.1039/b415959d

2004

[3] Nitroxide-Mediated Controlled Free-Radical Emulsion Polymerization of Styrene and n-Butyl Acrylate Using a Water-Soluble Alkoxyamine. Nicolas, J.; Charleux, B.*; Guerret, O.; Magnet, S. Angew. Chem., Int. Ed. 2004, 43, 6186. DOI: 10.1002/anie.200460704

[2] Novel SG1-Based Water-Soluble Alkoxyamine for Nitroxide-Mediated Controlled Free-Radical Polymerization of Styrene and n-Butyl Acrylate in Miniemulsion. Nicolas, J.; Charleux, B.*; Guerret, O.; Magnet, S. Macromolecules 2004, 37, 4453. DOI: 10.1021/ma049800a

2002

[1] Kinetic Study of Nitroxide-Mediated Controlled Free-Radical Polymerization of n-Butyl Acrylate in Aqueous Miniemulsion. Farcet, C.; Nicolas, J.; Charleux, B.* J. Polym. Sci., Part A: Polym. Chem. 2002, 40, 4410. DOI: 10.1002/pola.10531

Editorials

2020

[4] Hybrid Nanoparticle Composites. Winter, J.;* Nicolas, J.; Ruan, G. J. Mater. Chem. B. 2020, 8, 4713. DOI: 10.1039/D0TB90071K

2019

[3] A Chemical Centenary to Celebrate. Yang, Y.Y.;* Nicolas, J.* Nature. Chem. 2019, 11, 870. DOI: 10.1038/s41557-019-0334-6

2018

[2] Best Practices for New Polymers and Nanoparticulate Systems - How Not To Be Soft With Reporting Standards. Nicolas, J.*; Liu, S.; Zhao, D.; Caruso, F.; Reichmanis, E.; Buriak, J. M. Chem. Mater. 2018, 30, 6587. DOI: 10.1021/acs.chemmater.8b02088

2011

[1] Editorial. Fattal, E.;* Nicolas, J.; Tsapis, N. Int. J. Pharm. 2011, 416, 401. DOI: 10.1016/j.ijpharm.2011.05.018

Patents

2019

[6] Tsapis, N.; Nicolas, J.; Boissenot, T.; Bordat, A. Polymer Prodrugs and Subcutaneous and/or Intramuscular Administration Thereof. Patent WO 2019097025

2014

[5] Couvreur, P.; Nicolas, J.; Blin, T.; Chtourou, A.; Genevaz, N. Copolymers of Formula (I) and Uses. Patent WO 2015181504 (with LFB)

2012

[4] Bazile, D.; Couvreur, P.; Lakkireddy, H.; Nicolas, J. Functional PLA-PEG Copolymers, the Nanoparticles Thereof, their Preparation and Use for Targeted Drug Delivery and Imaging. Patent WO 2013127949 (with Sanofi)

2007

[3] Haddleton, D. M.; Khoshdel, E.; Nicolas, J. A Method for Derivatizing Hair with a Reactive Polyethylene Glycol. Patent WO 2008058989 (with Unilever)

2006

[2] Gérard, P.; Magnet, S.; Guerret, O.; Nicolas, J.; Charleux, B. Method for Preparing a Living Polymer Comprising Methacrylic and/or Methacrylate Units. Patent WO 2007057620 (with Arkema)

2004

[1] Charleux, B.; Guerret, O.; Magnet, S.; Nicolas, J. Method for Radical Emulsion Polymerization Using Hydrosoluble Alkoxyamines. Patent WO 2005082945 (with Arkema)

Book chapters

2018

[14] Drug-Initiated Synthesis of Cladribine-Based Polymer Prodrug Nanoparticles: Biological Evaluation and Structure Activity Relationships. Bao, Y.; Guégain, E.; Nicolas, J.* In Reversible Deactivation Radical Polymerization: Materials and Applications; Matyjaszewski, K.; Gao, H.; Sumerlin, B.; Tsarevski, N.; Chiefari, J. Eds.; ACS Symp. Ser.; American Chemical Society: Washington, DC, 2018, Vol. 1285, 201-217. DOI: 10.1021/bk-2018-1285.ch011

2016

[13] Bioconjugates and Biomaterials Prepared by Nitroxide-Mediated Polymerization. Harth, E. M.; Nicolas, J.* In Nitroxide-Mediated Polymerization: From Fundamentals to Applications in Materials Science; Gigmes, D. Ed.; RSC Polym. Chem. Ser. No. 19, 2016. ISBN 978-1782620617

[12] Nitroxide-Mediated Polymerization of Methacrylic Esters: How to Circumvent a Long-Time Obstacle. Nicolas, J.; Guégain, E.; Guillaneuf, Y.* In Nitroxide-Mediated Polymerization: From Fundamentals to Applications in Materials Science; Gigmes, D. Ed.; RSC Polym. Chem. Ser. No. 19, 2016. ISBN 978-1782620617

2015

[11] The Drug-Initiated Method: A Convenient Approach for the Synthesis of Efficient Polymer Prodrug Nanoparticles. Harrisson, S.; Maksimenko, A.; Bui, D. T.; Desmaële, D.; Couvreur, P.; Nicolas, J.* In Controlled Radical Polymerization: Materials; Matyjaszewski, K.; Sumerlin, B.; Tsarevski, N.; Chiefari, J. Eds.; ACS Symp. Ser.; American Chemical Society: Washington, DC, 2015, Vol. 1187, 257-272. DOI: 10.1021/bk-2015-1188.ch016

[10] Kinetic Studies of Elementary Reactions in SET-LRP / SARA ATRP. Nicolas, J.; Perrier, S.; Harrisson, S.* In Controlled Radical Polymerization: Mechanisms; Matyjaszewski, K.; Sumerlin, B.; Tsarevski, N.; Chiefari, J. Eds.; ACS Symp. Ser.; American Chemical Society: Washington, DC, 2015, Vol. 1187, 129-143. DOI: 10.1021/bk-2015-1187.ch007

2014

[9] Living Radical Polymerization: Nitroxide-Mediated Polymerization. Nicolas, J.; Guillaneuf, Y. In Encyclopedia of Polymeric Nanomaterials; Kobayashi, S. and Mullen, K. Eds.; Springer: New York, 2014, 1-16. ISBN 978-3-642-29647-5

[8] Polymer-Protein/Peptide Bioconjugates. Wilson, P.; Nicolas, J.; Haddleton, D. M. In Chemistry of Organo-Hybrids: Synthesis and Characterization of Functional Nano-Objects; Lacôte, E.; Charleux, B.; Copéret, C. Eds.; Wiley-VCH, 2014, 465-502. ISBN: 978-1-118-37902-8

2013

[7] Polymeric Nanoparticles for Drug Delivery. Andrieux, K.; Nicolas, J.; Moine, L.; Barrat, G. In Polymeric Biomaterials: Medicinal and Pharmaceutical Applications, Volume 2; Dumitriu, S.; Popa, V. Eds.; CRC Press, 2013, 123-151. ISBN: 978-1420094688

2012

[6] Targeted Delivery Using Biodegradable Polymeric Nanoparticles. Fattal, E.; Hillaireau, H.; Mura, S.; Nicolas, J.; Tsapis, N. In Fundamentals and Applications of Controlled Release Drug Delivery; Siepmann, J.; Siegel, R. A.; Rathbone, M. J. Eds.; Advances in Delivery Science and Technology Series; Controlled Release Society, Springer, 2012, 255-288. ISBN: 978-1461408802

[5] Nitroxide-Mediated Polymerization. Nicolas, J.; Guillaneuf, Y.; Bertin, D.; Gigmes, D.; Charleux, B. In Polymer Science: A Comprehensive Reference; Matyjaszewski, K.; Möller, M. Eds.; Elsevier, 2012, 3, 277. ISBN: 978-0444533494

2011

[4] Poly(alkyl cyanoacrylate) Nanosystems. Nicolas, J.; Vauthier, C. In Intracellular Delivery: Fundamentals and Applications; Fundamental Biomedical Technologies; Prokop, A. Ed.; Springer, 2011, 225-250. ISBN: 978-9400712478

2010

[3] Controlled/Living Radical Polymerization in Aqueous Miniemulsion. Lefay, C.; Nicolas, J. In Miniemulsion Polymerization Technology; Mittal, V. Ed.; Scrivener Publishing: Salem, MA, 2010, 173-210. ISBN: 978-0470625965

2009

[2] Nitroxide-Mediated Controlled Free-Radical Copolymerization of Poly(ethylene glycol) Methyl Ether Methacrylate and Methacrylic Acid. Toward New Water-Soluble Macroinitiators. Dire, C.; Nicolas, J.; Brusseau, S.; Charleux, B.; Magnet, S.; Couvreur, L. In Controlled/Living Radical Polymerization: Progress in RAFT, NMP & OMRP; Matyjaszewski, K. Ed.; ACS Symp. Ser.; American Chemical Society: Washington, DC, 2009, Vol. 1024, 303-318. DOI: 10.1021/bk-2009-1024.ch020

2008

[1] Fluorescently Labeled Protein-Polymer Bioconjugates Using Protein Derived Macroinitiators from Living Radical Polymerization. Nicolas, J.; San Miguel, V.; Mantovani, G.; Haddleton, D. M. In Polymers for Biomedical Applications; Mahapatro, A.; Kulshrestha, A. S. Eds.; ACS Symp. Ser.; American Chemical Society: Washington, DC, 2008, Vol. 977, 78-94. DOI: 10.1021/bk-2008-0977.ch006

Proceedings

2014

[23] Novel Nanoparticles with In Vivo Anticancer Activity from Well-​Defined Polymer Prodrug Amphiphiles. Nicolas, J.; Harrisson, S.; Bui, D. T.; Maksimenko, A.; Couvreur, P. Abstracts of Papers, 248th ACS National Meeting, San Francisco, CA, United States, August 10-14, 2014, POLY-650

[22] Nitroxide-​Mediated Radical Ring-Opening Copolymerization: Towards the Design of Block Copolymers Comprising a Degradable Block. Delplace, V.; Tardy, A.; Guillaneuf, Y.; Gigmes, D.; Couvreur, P.; Nicolas, J. Abstracts of Papers, 248th ACS National Meeting, San Francisco, CA, United States, August 10-14, 2014, POLY-343

[21] Comproportionation, Activation, and Termination in SET LRP​/SARA ATRP. Harrisson, S.; Nicolas, J. Abstracts of Papers, 248th ACS National Meeting, San Francisco, CA, United States, August 10-14, 2014, POLY-222

[20] Toward Radical Ring-​Opening Living Polymerization via NMP: End-​Chain Characterization, Livingness, and Control. Delplace, V.; Tardy, A.; Guillaneuf, Y.; Gigmes, D.; Couvreur, P.; Nicolas, J. Abstracts of Papers, 248th ACS National Meeting, San Francisco, CA, United States, August 10-14, 2014, POLY-17

[19] New Biodegradable PEG-​Based Copolymers Synthesized by Nitroxide-​Mediated Radical Ring-​Opening Polymerization, for Biomedical Applications. Delplace, V.; Tardy, A.; Guillaneuf, Y.; Gigmes, D.; Couvreur, P.; Nicolas, J. Abstracts of Papers, 248th ACS National Meeting, San Francisco, CA, United States, August 10-14, 2014, POLY-624

[18] Novel Multifunctional Polymer Nanoparticles for Active Targeting in Drug Delivery: Application to Cancer and Alzheimer's Disease. Nicolas, J.; Le Droumaguet, B.; Brambilla, D.; Maksimenko, A.; Andrieux, K.; Couvreur, P. Abstracts of Papers, 248th ACS National Meeting, San Francisco, CA, United States, August 10-14, 2014, COLL-397

2012

[17] Gemcitabine-Polyisoprenoid Nanoparticles for Potential Application in Cancer Therapy. Nicolas, J.; Bui, D. T.; Maksimenko, A.; Harrisson, S.; Desmaële, D.; Couvreur, P. Polym. Prepr. (Am. Chem. Soc., Div. Polym. Chem.) 2012, 53, 19

[16] Functionalized Polymeric Nanocapsules of Perfluorooctyl Bromide.Diou, O.; Tsapis, N.; Delplace, V.; Nicolas, J.; Mackiewicz, N.; Robic, C.; Giraudeau, C.; Valette, J.; Fattal, E. Polym. Prepr. (Am. Chem. Soc., Div. Polym. Chem.) 2012, 53, 412

2011

[15] Design of Innocuous Polymethacrylates for Biomedical Applications by Nitroxide-Mediated Polymerization. Chenal, M.; Mura, S.; Harrisson, Couvreur, P.; Nicolas, J. Polym. Prepr. (Am. Chem. Soc., Div. Polym. Chem.) 2011, 52, 419

2010

[14] Nanoparticles Against Alzheimer's Disease: PEG-PACA Nanoparticles are Able to Link the Aβ-Peptide and Influence its Aggregation Kinetics. Brambilla, D.; Verpillot, R.; Taverna, M.; De Kimpe, L.; Le Droumaguet, B.; Nicolas, J.; Canovi, M.; Gobbi, M.; Mantegazza, F.; Salmona, M.; Nicolas, V.; Scheper, W.; Couvreur, P.; Andrieux, K. J. Control. Rel. 2010, 148, e112

2008

[13] Site-Directed Conjugation of Clicked Glycopolymers To Form Glycoprotein Mimics. Haddleton, D. M., Mantovani, G.; Lindqvist, J.; Jones, M. W.; Brayden, D.; Ryan, S.; Randev, R.; Nicolas, J. Polym. Prepr. (Am. Chem. Soc., Div. Polym. Chem.) 2008, 49, 1089

[12] Nanostructured Latex Particles Directly Obtained by Nitroxide-Mediated Emulsion Polymerization. Nicolas, J.; Ruzette, A.-V.; Charleux, B.; Magnet, S.; Gérard, P. Polym. Prepr. (Am. Chem. Soc., Div. Polym. Chem.) 2008, 49, 205

[11] Toward the Synthesis of Clickable, Stealth Nanoparticles Based on Poly(alkyl cyanoacrylate). Nicolas, J.; Borretto, E.; Desmaële, D.; Andrieux, K.; Couvreur, P. Polym. Prepr. (Am. Chem. Soc., Div. Polym. Chem.) 2008, 49, 488

[10] Nitroxide-Mediated Controlled Free-Radical Polymerization of Poly(ethylene Glycol)-Based Monomers. Nicolas, J.; Couvreur, P.; Charleux, B. Polym. Prepr. (Am. Chem. Soc., Div. Polym. Chem.) 2008, 49, 215

2006

[9] Fluorescently Tagged Bioconjugates from Living Radical Polymerization Using Protein Macroinitiators. San Miguel, V.; Nicolas, J.; Mantovani, G.; Haddleton, D. M. PMSE Prepr. (Am. Chem. Soc., Div. Polym. Mater. Sci. Eng.) 2006, 95, 1064

[8] Nanoparticles Synthesized by Novel Nitroxide-Mediated Emulsion Polymerization Processes. Nicolas, J.; Haddleton, D. M.; Khoshdel, E. Polym. Prepr. (Am. Chem. Soc., Div. Polym. Chem.) 2006, 47, 903

[7] Bioconjugation onto a Biological Surface Using Fluorescent Polymers Synthesized by Living Radical Polymerization. Nicolas, J.; Haddleton, D. M.; Khoshdel, E. Polym. Prepr. (Am. Chem. Soc., Div. Polym. Chem.) 2006, 47, 15

[6] Strong Improvement of Nitroxide-Mediated Polymerizations of Methyl Methacrylate by a Copolymerization Approach: Polymer Synthesis and Characterizations. Nicolas, J.; Mueller, L.; Belleney, J.; Charleux, B. Abstracts of Papers, 231st ACS National Meeting, Atlanta, GA, United States, March 26-30, 2006

2005

[5] Polymerization in Aqueous Dispersed Media Stabilized by Polyelectrolyte Copolymers. Delaittre, G.; Houillot, L.; Lefay, C.; Manguian, M.; Nicolas, J.; Chassenieux, C.; Save, M.; Charleux, B. 2nd Workshop of the Young European Scientists (YES 2005), Krakow, Poland, September 13-18, 2005, P_056[2005]

[4] Strong Improvement of Nitroxide-Mediated Controlled Free-Radical Polymerization of Methyl Methacrylate via a Copolymerization Approach. Nicolas, J.; Charleux, B.; Guerret, O. Polym. Prepr. (Am. Chem. Soc., Div. Polym. Chem.) 2005, 46, 403

[3] Use of a Novel Class of SG1-Based Water-Soluble Dialkoxyamine in Nitroxide-Mediated Controlled Free-Radical Emulsion Polymerization. Nicolas, J.; Charleux, B.; Guerret, O.; Magnet, S. Polym. Prepr. (Am. Chem. Soc., Div. Polym. Chem.) 2005, 46, 484

2004

[2] Water-Soluble Alkoxyamine: Application as New Initiator in Aqueous Dispersed Systems. Nicolas, J.; Charleux, B.; Guerret, O.; Magnet, S. 40th International Symposium on Macromolecules - World Polymer Congress MACRO 2004, Paris, France, July 4-9, 2004, L1027

[1] Nitroxide-Mediated Controlled Free-Radical Emulsion Polymerization with a Novel SG1-Based Water-Soluble Alkoxyamine. Nicolas, J.; Delaittre, G.; Lefay, C.; Charleux, B.; Guerret, O.; Magnet, S. 40th International Symposium on Macromolecules - World Polymer Congress MACRO 2004, Paris, France, July 4-9, 2004, L1054